Oral route of drug administration is the most common and preferred route of administration. Oral dispersible tablets (ODT) are oral solid dosage forms that disintegrate in the oral cavity in easy swallow residue. Linagliptin which is an oral dipeptidyl peptidase (DPP-4) inhibitor indicated as an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus (T2DM). Linagliptin which practically shows poor solubility. The project was aimed to enhance the solubility which in turn improves the bioavailability. DESIGN EXPERT version 8.0.7.1 was selected for designing of the present project to make the project economical and statically significant. Superdisintegrants (croscarmellose sodium, sodium starch glycolate and crospovidone) used in different concentrations. Prepared tablets were evaluated for various in-vitro evaluation tests such as weight variation, thickness, wetting time, drug content, in-vitro disintegration time, in-vitro dissolution. The formulations are analyzed for considered response i.e. disintegration, dissolution with the help of DESIGN EXPERT software and the based on the considered responses an optimized formulation was developed. The Optimized Formulation showed in-vitro drug release 99.45% and is the best formulation.
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